Comtan and/or Equivalents

Drug	Related Drug Names
Comtan 200mg and/or Equivalents	Comtan, Entacapone, Sandoz-Entacapone

Comtan (Entacapone)

Comtan Description

Comtan or Entacapone belongs to the class of drugs called nitrocatchols and is used to treat Parkinson’s disease. The drug Comtan is a COMT or catechol O methyl transferase inhibitor. Comtan, along with drugs like levodopa and carbidopa are used to treat symptoms such as poor muscle control, muscle spasms, tremors, and stiffness associated with Parkinson’s disease. Sometimes doctors use Comtan to treat other symptoms and conditions as well. When Comtan is used in conjunction with levodopa and carbidopa, levodopa levels in the body as well as the efficacy of the drug levodopa are maximized.

Conditions Treated by Comtan

Comtan is used to treat Parkinson’s disease and its different symptoms

Dosage Information

a.) Typical dosage recommendations

If you are being treated for Parkinson’s disease, your doctor will recommend one 200 mg Comtan tablet to be taken with each and every dose of levodopa and carbidopa. You may have to take this up to 8 times (8 tablets) every day. If you suffer from Dyskinesia or cosume more than 800 mg of levodopa daily, your doctor may reduve the dosage of levodopa carbidopa. This is because Comtan maximizes the blood levels of levodopa carbidopa. You cannot and should not adjust your Comtan dose by yourself without the specific instructions from your doctor. Your doctor may increase or decrease your Comtan dosage depending on factors like other existing medical conditions, other medicines you consume and bothersome side effects.

b.)Missing a dose

If you for some reason have missed a dose, take it when you remember. If you forget to take your dose at the usual time and it is almost time for the next dosage, take the tablet at the next regular schedule and skip the missed dose. You should not consume additional Comtan pills to compensate for missed doses.

c.) Overdosing

Symptoms of Comtan overdose include convulsions, seizures, breathing difficulties, loss of coordination and weakness. Contact your nearest ER immediately if you think you have overdosed on Comtan.

Comtan Warnings

Inform your healthcare provider before taking Comtan if you suffer from any of the following:

• Food allergies, allergies to preservatives, dyes
• Hepatitis, cirrhosis, liver failure and other kinds of liver diseases
• Renal or kidney failure and kidney diseases
• Asthma, COPD and other kinds of lung diseases
• Gallbladder disease or bile duct obstruction

If you are breastfeeding, trying to conceive or are already pregnant, inform your healthcare provider. Comtan is a pregnancy category C drug that is unsafe for consumption while pregnant. Because Comtan can make you drowsy without any warning, you should not operate heavy machinery or drive a vehicle while under the influence of Comtan. Comtan cannot combat parkinson’s disease alone, so it should always be used in conjunction with levodopa and carbidopa products like Parcopa or Sinemet. If you want to stop taking Comtan, do it under your doctor’s supervision and approval. Abrupt discontinuation of this drug can cause neuroleptic malignant syndrome which can be pretty dangerous.

Side Effects

The following side effects have been reported from the users of Comtan.

• Stomach pain or abdominal pain - up to 8 percent
• Dizziness - up to 8 percent
• Hypokinesia or slow, diminished muscle movements - up to 9 percent
• Hyperkinesia or excessive muscle movements - up to 10 percent
• Urine discoloration - up to 10 percent
• Diarrhea - up to 10 percent
• Nausea - up to 14 percent
• Dyskinesia or involuntary body movements - up to 25 percent

Some other commonly reported side effects include the following: (1-6 percent of patients)

• Bacterial infection
• Weakness
• Fatigue
• Purpura or purple/red colored spots that resemble bruises
• Gas
• Heartburn
• Indigestion
• Dry Mouth
• Vomiting
• Constipation
• Taste changes
• Back pain
• Increased sweating

Serious side effects of Comtan are rare, but if they occur you should immediately contact your healthcare provider. Serious side effects of Comtan are:

• Unusual and intense urges to indulge in risky carnal activities or an inexplicable urge to gamble
• Severe muscle pain
• Severe diarrhea
• Digestive tract bleeding
• Fainting
• Hypertension
• Hypotension
• Balance or falling problems
• Priapism or a painful penile erection which refuses to subside
• Skin cancer known as malignant melanoma
• Heart attack
• Seizures
• Low levels of blood platelets or red blood cells or white blood cells
• Duodenal or intestinal ulcers
• Allergic reactions
• Difficulty in breathing
• Wheezing
• Swelling of the throat or mouth
• Itching
• Hives
• An unexplained rash
• Suicidal behaviours or thoughts
• Depression
• Anxiety
• Agitation
• Paranoia
• Delusions
• Hallucinations

If you stop taking Comtan too abruptly, you may experience NMS symptoms such as:

• Arrhythmias or irregular heart rhythms
• Sweating
• Tachycardia or a faster heart rate
• Irregular blood pressure
• Irregular pulse
• Confusion
• Stiff muscles
• High fever

You may experience none of the symptoms listed above or only a few of them. While taking Comtan, if you feel something is wrong or develop side effects, inform your healthcare provider immediately.

Comtan Drug Interactions

Comtan (entacapone) can cause drowsiness. Medicines for treating anxiety, depression, seizures, muscle relaxers, sleeping pills, narcotic pain medication and allergy or cold medicines can add to this drowsiness. Other kinds of Parkinson’s medications can interfere with Comtan. So you need to inform your doctor promptly if you take other Parkinson’s medicines or any other kind of prescription or over the counter drugs. You also need to inform your doctor about any kind of herbal products, mineral or vitamin supplements you may take. Following is a list of drugs that can interfere with Comtan:

• Antibiotics like erythromycin, chloramphenicol, ampicillin, erythrocin and rifampin
• Benemid or probenecid
• Aldomet or methyldopa
• Medihaler-Iso, Isuprel or isoproterenol
• Bronkometer, Bronkosol, isoetharine
• Epipen or epinephrine
• Dobutrex or dobutamine
• Questran, Prevalite or cholestyramine
• Tornalate or bitolterol
• Apokyn or apomorphine

If you are taking any of these, please inform your doctor.

If you have any questions about buying discount Comtan online or any other prescription products you can contact our team of professional Patient Service Representatives or one of our pharmacists 24-7 by calling 1-800-226-3784.

Notice: The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Comtan and/or Equivalents warnings, side-effects and general information