Prempro and/or Equivalents

Prempro (conjugated estrogen/medroxyprogesterone)

Prempro Description

The drug Prempro is used for treating dryness, burning and irritation around the vagina, hot flashes, night sweats and also to foil osteoporosis caused from thinning of the bones. All these symptoms are usually resultants of menopause in women. A grouping of conjugated estrogens and medroxyprogesterones is contained in Prempro. The ovaries in women produce sex hormones called estrogens, which aid in many body processes. A mixture of these estrogen hormones accounts for the conjugated estrogens. Commonly known as progesterone, medroxyprogesterones is another kind of a female hormone, which helps regulating the ovulation and menstruation processes. The drug is prescribed for women undergoing a natural menopause. However, Prempro medication is only a hormone therapy and will not help prevent diseases of the heart or dementia. It will rather raise the chances of developing these conditions.

Conditions Treated by Prempro

Vaginal symptoms, night sweats and women normally experience hot flashes during the menopause stage. Prempro consumed in low doses of 0.3 mg/1.5 mg and 0.45 mg/1.5 mg, provides effective relief from the symptoms. The frequency and intensity with which hot flashes and night sweats occur are significantly reduced. The difference can be noticed in less than 2 to 3 weeks. Osteoporosis is increasingly becoming common in postmenstrual women. The thinning of the bones makes them prone to fracturing their spine, hips and wrists. Prempro helps increase the density of bone minerals at the hips and spine thus averting osteoporosis. In any case, Prempro has proven to be one of the most appropriate medications for disruptive hot flashes and night sweats.

Prempro Dosage Information

a.) Typical Dosage Recommendations

The drug Prempro is available in various strengths of dosage, which also include two formulations of low-dose. These varied dosage strengths are designed such that it is easy for you and your physician to decide and conclude on the most suitable for you. Therefore, it is recommended that you consult your healthcare professional to help you with selecting the right dosage strength for your treatment. Experts advise on the usage of low effective doses of Prempro for a short time period. Low doses, themselves, have proven to be effective in relieving the sufferer from the symptoms of menopause. Anyhow, the treatment plan can be reviewed once you start to make regular visits to your physician. However, you need not worry about being on hormonal therapy for your complete life, since Prempro works best during short duration treatments.

b.) Missing a Dose

In order to obtain the best of results from Prempro medication, you must take it regularly as per your physician’s prescription. Well, in case you happen to miss a dose, take it as soon as you realize it. But if it is time for your next dose that is due, leave out the missed dose and use only the one that is due. Make sure that you do not take two doses at a time in order to catch up on your missed dose.

c.) Overdosing

If you have overdosed on Prempro, dial the emergency line immediately since a quick medical supportive care will be required. Overdosing of Prempro will make you suffer from nausea and vomiting, since the estrogen present in the drug causes irritation in the stomach. This drug overdose is also known to have caused vaginal bleeding in some women and young girls. Immediate treatment of the occurring symptoms is advised.

Prempro Warnings

Before your healthcare physician prescribes you a Prempro medication, is it important that you inform him/her about your medical history. The doctor should be informed if you have a history of blood clots, strokes or heart attacks, cancer, hypertension, renal failures, hypothyroidism, endometriosis, gallbladder diseases, liver diseases, high cholesterol and other such conditions. This is important since you should be treated for these risk factors prior to a hormonal therapy through Prempro. Drugs that contain estrogen are likely to increases chances of contracting breast cancer. If you are to undergo a surgery, it is advisable to stop a Prempro treatment about 4 to 6 weeks prior to the surgery to avoid blood clots. While undergoing a Prempro medication, if you are experiencing abnormal vaginal bleeding, inform your doctor for immediate medical attention since this may be a sign of cancer in the uterus. Under no circumstances should you use Prempro for treating dementia or preventing heart diseases. Moreover, those suffering from hypocalcaemia, which refers to lack of sufficient calcium levels in the blood, should be prescribed Prempro after proper deliberation. If you have experienced jaundice before, usage of Prempro is likely to cause it to recur. Congestive heart failure, ovarian cancer, hypothyroidism, gallbladder diseases and hypertension are few other symptoms Prempro medication is known to cause. If you are a breast-feeding mother, it is not wise to use Prempro since it is known to pass through the milk. Those experiencing dysfunctioning of the over, pulmonary embolism or those who are pregnant, must avoid Prempro medication.

Prempro Side Effects

Most common experienced side effects from using Prempro were:

• leg cramps
• painful menstruation
• breast pain and enlargement
• vaginitis due to yeast, and vaginal bleeding
• Chloasma or melasma from discontinuation of drug
• retinal vascular thrombosis
• steepening of the corneal curvature
• increase in blood pressure
• mood disturbances
• insomnia
• mental depression
• headaches

Some may suffer from:

• sudden increase or decrease in weight
• changes in libido
• backache
• fatigue and increased triglycerides

Possible Drug Interactions with Prempro

• St. John's Wort
• carbamazepine (Tegretol, Carbatrol)
• Phenobarbital (Luminal, Solfoton)
• rifampin (Rifadin, Rifater, Rifamate, Rimactane)
• ritonavir (Norvir)
• Antibiotics:
  • Biaxin (clarithromycin)
  • Erythromycin (E.E.S., Ery-Tab, Erythrocin, E-Mycin)
  • Sporanox (itraconazole)
  • ketoconazole (Nizoral)

It is wise to discuss with your healthcare provider about your ongoing medications prior to a treatment using Prempro. Combining Prempro with barbiturates, seizure or thyroid medications pave way for drug interactions. A combination of Prempro with barbiturates, although not dangerous, will make the former treatment less effective. It is the same with seizure medications too. Your body as a result of the combination metabolizes the hormones in Prempro too quickly. If medication for hypothyroidism is taken along with Prempro, your doctor may increase your dosage of the thyroid medication. Antibiotics or antifungal medicines, when taken along with Prempro, will decrease your liver's ability to metabolize the latter. All these drug interaction increase the risk of experiencing various side effects conditions.

If you have any questions about buying discount Prempro online or any other prescription products you can contact our team of professional Patient Service Representatives or one of our pharmacists 24-7 by calling 1-800-226-3784.

Notice: The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

Prempro and/or Equivalents warnings, side-effects and general information